London, United Kingdom
The position of Senior Statistical Bioinformatician within the Bioinformatics Core Facility will provide primarily statistical and mathematical expertise to support high throughput post-genomic technologies, within an informed biological context, not only for research scientists within the Francis Crick Institute but also for other members of the Core group. In addition, this role will provide support and training in statistics and bioinformatics where needed.
This position will be part of an already existing Core team of 14, including two mathematicians, providing bioinformatics, statistical and mathematical expertise to the Crick scientists. Everything the team does is directly driven by questions from Crick scientists, but this role has particular emphasis on ensuring the work we do is statistically sound and mathematically motivated.
In this role you will be asked to provide mathematical, bioinformatics and data analysis support to projects run by Francis Crick scientists. Using a variety of programming, statistical and data analysis techniques you will provide answers to questions that scientists ask mostly about the latest high throughput genomic technologies. Typical analysis steps will cycle through quality assessment, results generation, biological interpretation and ultimately named publication. During this process you will be expected to work closely with other members of the bioinformatics team, the scientific groups with which you are collaborating and the advanced sequencing team. As well as analysis from more established applications there will be the opportunity to develop methods and algorithms to support more bespoke applications requiring the development of new pipelines and software. There will also be mathematical consultation to other members of the group and scientists from the 100 research groups in the Institute. One of the most recent protocols is for Spatial Transcriptomics which we would like to implement at the Crick.
These include but not limited to:
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a brand new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under a single roof in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; to developing emerging talent and exporting it the rest of the UK; to public engagement; and to helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
KEY EXPERIENCE AND COMPETENCIES
The post holder should embody and demonstrate our core Crick values: Bold, Imaginative, Open, Dynamic and Collegial, in addition to the following:
Skills and Competencies
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